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Elevated blood pressure (BP) is a major risk factor for cardiovascular disease. Both age and obesity are associated with a raised BP. Overweight and obesity are associated with insulin resistance (IR). The role of insulin in BP regulation in the elderly is less well defined. The aim of this study was to examine the role of insulin resistance and blood glucose in blood pressure regulation in the elderly. This was a secondary analysis of a multicenter trial of a vitamin-E-supplemented intervention to lower blood pressure in elderly people. The study was conducted at community hospitals. Ninety elderly people with a history of treated hypertension were recruited. Of these, 19 were randomized to vitamin E (800 IU/day) and 61 to placebo for a total of 80 individuals with high BP. These people were studied at baseline, 3 months and 6 months. The data were collected as part of routine blood tests and then analyzed in a blinded fashion. Systolic and diastolic blood pressures were reduced in the vitamin E group at 3 months and 6 months compared to placebo (systolic blood pressure -4.6 mmHg, 95% confidence interval [CI] -7.0 to -2.3, p ac619d1d87
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